Swimming at the 2006 Central American and Caribbean Games – Men's 4x100 metre medley relay

The men's 4x100m Medley Relay event at the 2006 Central American and Caribbean Games occurred on Saturday, July 22, 2006 at the S.U. Pedro de Heredia Aquatic Complex in Cartagena, Colombia.

Only 8 relays were entered in the event, and consequently, it was only swum once (in finals).

Records at the time of the event were: