Sulfadiazine
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| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682130 |
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Topical cream, by mouth |
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| Bioavailability | ? |
| Metabolism | ? |
| Biological half-life | ? |
| Excretion | ? |
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| ECHA InfoCard | 100.000.623 |
| Chemical and physical data | |
| Formula | C10H10N4O2S |
| Molar mass | 250.278 g/mol |
| Melting point | 252 to 256 °C (486 to 493 °F) |
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Sulfadiazine is an antibiotic. Used together with pyrimethamine it is the treat of choice for toxoplasmosis. It is a second line treatment for otitis media, prevention of rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae. It is taken by mouth.
Common side effects include nausea, diarrhea, headache, fever, rash, depression, and pancreatitis. It should not be used in people who have severe liver problems, kidney problems, or porphyria. If used during pregnancy it may increase the risk of kernicterus in the baby. It is believed to be safe during breastfeeding if the baby is otherwise healthy. It is in the sulfonamide class of medications.
Sulfadiazine was approved for medical use in the United States in 1941. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Sulfadiazine is available as a generic medication. The wholesale cost in the developing world is about 2.70 to 7.32 USD a month. In the United States treatment costs more than 200 USD a month.
It eliminates bacteria that cause infections by stopping the production of folate inside the bacterial cell, and is commonly used to treat urinary tract infections, and burns.
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