Subclinical

In medicine, a disease is considered asymptomatic if a patient is a carrier for a disease or infection but experiences no symptoms. A condition might be asymptomatic if it fails to show the noticeable symptoms with which it is usually associated. Asymptomatic infections are also called subclinical infections. Other diseases (such as mental illnesses) might be considered subclinical if they present some but not all of the symptoms required for a clinical diagnosis. The term clinically silent is also used.

Knowing that a condition is asymptomatic is important because:

An example of an asymptomatic disease is Cytomegalovirus (CMV) which is a member of the herpes virus. "It is estimated that 1% of all newborns are infected with CMV, but the majority of infections are asymptomatic." (Knox, 1983; Kumar et al. 1984) In some diseases, the proportion of asymptomatic cases can be important. For example in multiple sclerosis it is estimated that around 25% of the cases are asymptomatic, being these cases detected postmortem or just by coincidence (as incidental findings) while treating other diseases.

Asymptomatic conditions may not be discovered until the patient undergoes medical tests (X-rays or other investigations). Some people may remain asymptomatic for a remarkably long period of time; such as people with some forms of cancer. If a patient is asymptomatic, precautionary steps must be taken.

A patient's individual genetic makeup may delay or prevent the onset of symptoms.

Some diseases are defined only clinically, like AIDS being opposed to HIV infection. Therefore it makes no sense to speak about "asymptomatic AIDS". This concept of clinically defined diseases is related in some way to the concept of syndrome.

These are conditions for which there is a sufficient number of documented individuals that are asymptomatic that it is clinically noted. For a complete list of asymptomatic infections see subclinical infection.

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