Streptomyces clavuligerus
| Streptomyces clavuligerus | |
|---|---|
| Scientific classification | |
| Kingdom: | Bacteria |
| Phylum: | Actinobacteria |
| Order: | Actinomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. clavuligerus |
| Binomial name | |
|
Streptomyces clavuligerus Higgens & Kastner 1971 |
|
Streptomyces clavuligerus is a species of Gram-positive bacterium notable for producing clavulanic acid.
S. clavuligerus ATCC 27064 (NRRL 3585, DSM 738) was first described by Higgens and Kastner, who isolated it from a South American soil sample. Its name refers to the shape of its spore-bearing hyphal branches: from the Latin, clavula, meaning little club, and igerus, meaning bearing. S. clavuligerus spores are gray to grayish-green.
S. clavuligerus produces over 20 secondary metabolites, including many beta-lactam antibiotics such as clavulanic acid, cephamycin C, deacetoxycephalosporin C, penicillin N (an intermediate in cephamycin C pathway), and at least four other clavams. Non-β-lactam antibiotics include holomycin and an antibiotic complex, MM 19290, related to tunicamycin; a beta-lactamase-inhibitory protein (BLIP) has also been described.
Another important characteristic of S. clavuligerus is that it is not able to use glucose as a carbon source because it lacks a glucose transport system.
It also possesses all the enzymes of the urea cycle, which is unusual for a prokaryote, although it is not clear whether the urea cycle is functional.
Alvarez-Alvarez, R.; Rodriguez-Garcia, A.; Santamarta, I.; Perez-Redondo, R.; Prieto-Dominguez, A.; Martinez-Burgo, Y.; Liras, Paloma (May 2014). "Transcriptomic analysis of Streptomyces clavuligerus Delta ccaR:: tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation". Microbial Biotechnology. 7 (3): 221–231. doi:10.1111/1751-7915.12109.
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