"Straight to the Bank" is the first single from 50 Cent's third album, Curtis. The song is produced by Ty Fyffe, with additional production from Dr. Dre.Tony Yayo contributes with a laughing effect in the chorus. This stuttered laughing effect was then later copied by Lupe Fiasco on his song, The Coolest, from Lupe Fiasco's The Cool.

Six days after the song was leaked on the Internet, it debuted at number 48 on the Hot R&B/Hip-Hop Songs and peaked at number 30 weeks later. "Straight to the Bank" debuted at #32 on the Billboard Hot 100 on the week of May 26, 2007. It remained on the chart for 3 weeks, before falling off. 50 Cent performed the song live for the first time at the highly touted WBC Super Welterweight Championship fight between Floyd Mayweather Jr. and Oscar De La Hoya on May 5, 2007, at the MGM Grand in Las Vegas, Nevada, while leading Mayweather's entourage into the ring. At its highest, "Straight to the Bank" hit number 3 on the iTunes single chart; however, due to the Curtis album being delayed, the song was removed from the iTunes library.

The music video debuted on MTV on May 17, 2007, after the "Amusement Park" video, which was released on May 16, 2007. On December 31, 2007, the music video appeared at number 83 on BET's Notarized: Top 100 Videos of 2007 countdown. The music video features cameos by G-Unit members Spider Loc and Tony Yayo, who contributes uncredited vocals to the song. The song has over 32 million views on YouTube.

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