Stippled chromatin

In pathology, salt-and-pepper chromatin, also salt-and-pepper nuclei and stippled chromatin, refers to cell nuclei that demonstrate granular chromatin (on light microscopy).

Salt-and-pepper chromatin is typically seen in endocrine tumours such as medullary thyroid carcinoma, neuroendocrine tumours and pheochromocytoma.

A pheochromocytoma showing finely granular chromatin. H&E stain.

A pheochromocytoma showing finely granular chromatin. H&E stain.

Salt-and-pepper chromatin (pheochromocytoma). H&E stain.

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