Stewie Kills Lois and Lois Kills Stewie

"Stewie Kills Lois" "Lois Kills Stewie"
Family Guy episode
Promotional poster of the two episodes.
Episode no.	Season 6 Episode 4/5
Directed by	John Holmquist ("Stewie Kills Lois") Greg Colton ("Lois Kills Stewie")
Written by	David A. Goodman ("Stewie Kills Lois") Steve Callaghan ("Lois Kills Stewie")
Production code	5ACX17/5ACX18
Original air date	November 4, 2007 ("Stewie Kills Lois") November 11, 2007 ("Lois Kills Stewie")
Guest appearance(s)
Patrick Stewart as Avery Bullock Paula Abdul as herself Randy Jackson as himself Simon Cowell as himself
Episode chronology
← Previous "Believe It or Not, Joe's Walking on Air" Next → "Padre de Familia"
Family Guy (season 6) List of Family Guy episodes

"Stewie Kills Lois" and "Lois Kills Stewie" is a two-part episode of the sixth season of the animated comedy series Family Guy, which was originally produced for the end of Season 5. Respectively, both are the fourth and fifth episode of their season, and they premiered in the United States on Fox on November 4 and 11, 2007. In the former, housewife Lois receives cruise tickets from anthropomorphic dog Brian, and invites Peter on the cruise with her. This upsets Stewie, and he ultimately appears to murder Lois while she is on the cruise, only to find out that she had survived the attack as the year passes. In the latter, Lois is able to expose Stewie as the villain that he is, but he soon accomplishes his dream of world domination.

"Stewie Kills Lois" was written by David A. Goodman and directed by John Holmquist, while "Lois Kills Stewie" was written by Steve Callaghan and directed by Greg Colton. Both episodes received relatively positive reviews for their combined story arc and cultural references. "Lois Kills Stewie" featured appearances by Patrick Stewart, Paula Abdul, Randy Jackson, Simon Cowell, and Willem Dafoe (although Dafoe did not provide his voice) and both episodes featured cameos by various recurring voice actors for the series.

On Lois' birthday, Brian gives her a pair of cruise tickets with the intention of going with her. She invites Peter instead, disappointing Brian. Stewie is also upset at not being invited on the cruise, and he concocts a plan to embarrass Lois upon her return. Brian points out that Stewie has never followed through with any of his plans to hurt Lois. Stewie, disappointed in himself, resolves to prove Brian wrong. Meanwhile, on the cruise, Peter proves to be a frequent source of embarrassment for Lois, defecating on the poop deck and telling inappropriate stories at a dinner with ship's captain. Outraged, Lois walks onto the deck to be away from him, but is confronted by Stewie, who has traveled to the ship via speedboat. He shoots her repeatedly with a submachine gun, sending her overboard.