The Region of Stettin (German: Regierungsbezirk Stettin, Polish: rejencja szczecińska) was a unit of territorial division in the Prussian and later German Province of Pomerania. It was established in 1816 and existed until 1945. On 1 October 1932 the Stralsund Region was incorporated into the Stettin Region. The Region included large parts of the historical regions of Western and Central Pomerania.
The seat of the regional administration was the city of Stettin (modern Szczecin). Initially it was located in the Ducal Castle, in 1911 it was moved to a new building complex.