Set in the 24th century, the series follows the adventures on Deep Space Nine, a space station located near a stable wormhole between the Alpha and Gamma quadrants of the Milky Way Galaxy. In this episode, Dr. Bashir (Alexander Siddig) attempts to help four fellow augments start becoming useful and productive members of society.

Parents who allow their children to be genetically manipulated attempt to keep the procedure secret: It is illegal, and augmented human beings are prohibited from joining most professions and may not join Starfleet. However, the problems developed by these four augments forced their parents to seek medical help for them. The four have been institutionalized for most of their lives, and as such are very close to each other, but mistrust outsiders, even their own doctor, Dr. Loews (Jeanetta Arnette).

The four augments are:

With Federation/Dominion peace negotiations in the background, Dr. Bashir (Alexander Siddig) decides to take time to help less fortunate augments with their problems. He is introduced to four augments who, due to unintended side effects, are unable to function in society.

Bashir realizes that his patients' primary problem is boredom. As Jack (Tim Ransom) has pointed out, they are forbidden from pursuing any profession where they could put their brain power to work. Meanwhile, Damar (Casey Biggs) has become the new leader of the Cardassian Union and offers peace talks with the Federation. Watching his speech, the augments make several incredibly accurate guesses about Damar and how he came to power, including that he murdered the "princess" (Tora Ziyal) of the "deposed king" (Dukat). Bashir convinces Captain Sisko (Avery Brooks) to allow the augments to review the peace negotiations to see if they can determine the Dominion's agenda.

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