Friday Night Stand-up with Greg Giraldo was a programming block hosted by Greg Giraldo on Comedy Central in the USA from 8-11 pm on Friday nights. The first show was in 2005. Giraldo interviewed guests in front of a live audience while introducing comedy specials.
Comedians who have appeared include Jeff Dunham, Carlos Mencia and Dane Cook. In 2006, the title was changed to Stand-Up Nation with Greg Giraldo.