St. Mary's College was a Catholic college in Delaware from 1841 until 1866.
St. Mary's College was founded in Wilmington, Delaware, in 1841 by Patrick Reilly. Incorporated January 29, 1847 by an Act of The state of Delaware sec 793 chapter 44. Its enrollment peaked at 120 students in 1857. Its fortunes declined during the American Civil War and it closed in 1866.