"Something's Got a Hold on Me" is a song by American singer Etta James. The song was written by James, Leroy Kirkland and Pearl Woods, while production was handled by Leonard and Phil Chess. It was released in 1962 as the third single from her 1962 self-titled album as a 7" vinyl disc. Musically, "Something's Got a Hold on Me" is an R&B track with elements of soul, blues and gospel. Upon its release, the single was an R&B hit, peaking at number four on the Billboard Hot R&B Sides chart.

"Something's Got a Hold on Me" has been covered and sampled by various contemporary artists. Pretty Lights sampled the song on his 2006 album Taking Up Your Precious Time. In 2010, American singer-songwriter Christina Aguilera recorded a cover version of the song on the soundtrack Burlesque. In 2011, the track was sampled on two hits: "Levels" by Swedish DJ Avicii and "Good Feeling" by American rapper Flo Rida. Australian recording artist Jessica Mauboy also covered "Something's Got a Hold on Me" in 2013 and released it as a single.

"Something's Got a Hold on Me" was written by Etta James, Leroy Kirkland and Pearl Woods, while it was produced by two founders of the Chess Records, Leonard and Phil Chess. The song was released as the third single from James' 1962 self-titled studio album. It was served as a 7" vinyl disc with the other song, "Waiting for Charlie to Come Home", as the B-side in the United States. Later, the track was included on the singer's 1963 compilation album Etta James Top Ten. The live version of "Something's Got a Hold on Me" also appeared on Etta James' first live album, Etta James Rocks the House (1964). In 1992, the song was a part of her greatest hits album, My Greatest Songs.

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