The Smyrna River is a 7.3-mile-long (11.7 km) river in central Delaware in the United States.
It rises east of Smyrna, Delaware, at the confluence of Duck Creek and Mill Creek. It flows generally northeast, forming the boundary between Kent and New Castle counties. It enters Delaware Bay approximately 6 miles (10 km) northeast of Smyrna. It is navigable for its entire course.