A patient is admitted to Princeton Plainsboro after reenacting the Crucifixion. During the initial conversation, the patient reveals that he crucified himself to honor a bargain he made with God for curing his daughter's cancer. Taub comes up with a sound diagnosis but the patient starts losing teeth so the team scraps the idea. However, Chase and Masters break into the patient's apartment to see that he has been starving himself which was the likely cause of the tooth loss. Regardless, the patient refuses the treatment because of the promise he made to God to save his daughter.

Meanwhile, Cuddy walls House for an apology about lying to her and also pulls him for the wedding dinner of the hospital's chairman-of-board. Chase takes Foreman to the wedding as a wingman and fixes him up with a girl, telling her that Foreman's his boss. At the end of the night, Chase takes off with that very girl and a friend of hers. While House and Cuddy start leaving for the rehearsal dinner, Cuddy makes a cynical remark by telling him that the marrying couple has only nineteen months because, in the state of New Jersey, couples can only divorce after 18 months of living separated, implying they would split-up after their honeymoon. House and Cuddy discuss Cuddy's wedding gown of preference and House says that it wouldn't be Cuddy's first marriage if she married. She says that it would, but deducing from her remark about New Jersey divorce laws, House says that he had checked the records stating that she was married for six days in 1987 and that she lied to him, but he forgives her. Cuddy storms off.

Taub notices his wife take her cellphone to the bathroom that morning and suspects that she's having an affair. Confronting her about it, he learns that she's been corresponding with somebody from an infidelity support group. At the wedding dinner, Taub and Rachel have an argument about her friend. Rachel stands her ground, implying taking revenge on Taub's adulterous past.

After the dinner, during a conversation with Taub, Foreman and Wilson, House gets an idea and runs back to the hospital. He visits the patient and tells him that the annual CT scans that his daughter receives were unable to detect tiny spots of remaining tumor and the PET scans he did revealed them. He concludes that the patient should receive the treatment because God had already broken the bargain. Embittered, the patient agrees. Later on, House reveals that he had been lying, but that the patient is recovering. Instead of losing his faith, he thinks that the proof that, even after accepting stem cell treatment, God did not punish him proves that God is merciful and all about love, as his daughter said.

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