Sisto Fabri (4 August, 1540 – 1594) was a theologian and canon lawyer of the Dominican Order who was appointed Master of the Sacred Palace by Pope Gregory XIII serving from 1580 to 1583, and Master of the Order of Preachers from 1583 to 1589.
Fabri was born 4 August 1540 at Villa Basilica, near Lucca, Italy. Shortly after his birth his family moved to Naples.
Fabri entered the Dominican Order in 1556 at the convent of Santa Caterina a Formiello. After completing his studies there Fabri began teaching there in 1563. Fabri was later sent to Bologna to study canon Law.
In the mid 1550s Fabri served as professor of theology at the Dominican studium at Santa Maria sopra Minerva, the forerunner of the Pontifical University of Saint Thomas Aquinas, Angelicum.
In 1571 he became the secretary of the Master of the Order of Preachers Serafino Cavalli whom he accompanied during his visitations to many provinces. Later Cavalli appointed Fabri as Provincial for the Holy Land and Procurator for the Order.
In 1576 while prior of the convent at Santa Maria sopra Minerva Fabri taught theology at the University of Rome. During this time he came to know Giordano Bruno who was a guest at the convent. During his priorship in 1577 the studium at the Minerva was reorganized in light of the generous donation of Juan Solano, O.P., former bishop of Cusco, Peru and became the College of St. Thomas, the forerunner of the Pontifical University of Saint Thomas Aquinas, Angelicum.