Sir William Clayton, 4th Baronet (16 April 1762 – 26 January 1834) was an English politician.
Clayton was the oldest surviving son of William Clayton (c. 1718–1783), who was the grand-nephew of Sir Robert Clayton, a wealthy banker and former Lord Mayor of London.
He was educated at Queen's College, Oxford. In 1785, he married Mary East, the daughter of Sir William East, 1st Baronet, a former High Sheriff of Berkshire. They had 5 sons and 2 daughters.
In 1783, he was elected unopposed was a Member of Parliament (MP) for the rotten borough of Great Marlow, succeeding his father. He held the seat until he stood down at the general election in 1790.
In 1799 he inherited the baronetcy of his first cousin Sir Robert Clayton. He died aged 71 on 26 January 1834, and was succeeded in the baronetcy by his eldest son, William Robert, who became an MP from Great Marlow from 1832 to 1842.