Sir Thomas Twisden, 1st Baronet (2 January 1602 – 2 January 1683) was an English lawyer and politician who sat in the House of Commons of England in two periods between 1646 and 1660. He was a High Court judge who presided at the trial of regicides.
Twisden was the second son of Sir William Twysden, 1st Baronet of Roydon, East Peckham, Kent and his wife Lady Ann Finch. He was admitted at Emmanuel College, Cambridge in 1614. He was admitted at the Inner Temple in November 1617 and called to the Bar in 1626. In 1646 he became a Bencher. He changed the spelling of his surname to Twisden.
Twisden was Recorder of Maidstone, and in 1646, he was elected Member of Parliament for Maidstone in the latter part of the Long Parliament but was excluded in 1648 under Pride's Purge.
Twisden became Sergeant at Law in 1654 and purchased the manor of Bradbourne House. East Malling, Kent in 1656. After the Restoration, he was MP for Maidstone again in 1660. He became a judge and was knighted in 1660 and presided at the trials of regicides. He was created a baronet, of Twisden of Bradbourne, Kent, on 13 June 1666.
Twisden married Jane Tomlinson, daughter of John Tomlinson, of St Michael's-le-Belfry, York. His son Roger succeeded to the baronetcy and his daughter Margaret married Sir Thomas Style, 2nd Baronet. His brother was the baronet under the original spelling Sir Roger Twysden, 2nd Baronet.