Sir Nicolas Byron (1416-1503) was an English nobleman, politician, and knight. He was the younger son of Sir John Byron (died 1450). He was created a Knight of the Bath by Arthur, Prince of Wales on the occasion Prince Arthur's marriage on 14 November 1501.
Sir Nicholas Byron married Joan Bushler, a daughter of Sir John Bushler of Haugham, Lincolnshire and Elizabeth Berkeley. He was the father of Sir John Byron (died 1567). Joan survived her husband and married Sir Gervase Clifton of Clifton, Nottingham.