Sir Lucius Henry O'Brien, 3rd Baronet PC (Ire) (2 September 1731 – 15 January 1795) was an Irish baronet and politician for 34 years.
O'Brien was the son of Sir Edward O'Brien, 2nd Baronet and his wife Mary Hickman, inheriting the baronetcy on the death of his father in 1765. He was educated at Trinity College, Dublin and entered the Middle Temple in 1753, later becoming a barrister.
In 1761, he entered the Irish House of Commons as the member for Ennis, sitting until 1768. Subsequently O'Brien successfully ran for Clare, a seat previously held by his father, holding it until 1776. He was then again elected for Ennis, but following the unseating of Hugh Dillon Massy as Member of Parliament for Clare, O'Brien returned to represent that constituency in 1778. In the election of 1783, he became the representative for Tuam. O'Brien was sworn of the Privy Council of Ireland in 1786. He served for the latter constituency until 1790, when he was re-elected for Ennis. He held this seat finally until his death in 1795.
He was elected a Fellow of the Royal Society in 1773.
O'Brien married Anne French, the daughter of Robert French, in 1768 and had by her seven children, three sons and four daughters. He was succeeded in the baronetcy as well as in the constituency of Ennis by his oldest son Edward.