James Lowther, 1st Earl of Lonsdale (5 August 1736 – 24 May 1802) was an English politician and landowner. He was a Member of Parliament for over twenty years before, in 1784, he was raised to the Peerage of Great Britain as Earl of Lonsdale.
The son of Robert Lowther and Catherine Pennington, he was educated at Peterhouse, Cambridge.
Lowther exercised influence over a number of "rotten" or "pocket" boroughs, including Appleby, a classic example of this type of constituency. In 1761 he was credited with securing the return of eight MPs — two each for Cumberland, Westmorland, and Cockermouth, and one each for Appleby and Carlisle.
He married Mary Crichton-Stuart, daughter of John Stuart, 3rd Earl of Bute and Mary Wortley-Montagu, 1st Baroness Mount Stuart on 7 September 1761 and he had a string of mistresses. He fell in love with the daughter of one of his tenants and made her his mistress keeping her in luxury. When she died he could not endure to have her buried and the body remained lying in bed until the increasing putrefaction became unbearable. He then had her body placed in a glass topped coffin that was placed in a cupboard. Eventually her body was buried in Paddington cemetery.
On 9 June 1792 he fought a duel with a Captain Cuthbert of the Guards, when the latter refused to let the former's carriage pass through Mount Street in London where some rioting had been taking place. The Earl asked him if he knew who he was which this led to an unpleasant exchange of words. Following which the Earl felt obliged to challenge the Captain to a duel the next morning. A pistol ball passed through the flap of Cuthbert's coat but after the exchange of fire both men were unhurt. The matter was concluded with a handshake.