Sir Henry Cobham (1537–1592) was an English diplomat.
The fifth son of George Brooke, 9th Baron Cobham, he was always known as, and signed himself, Henry Cobham. He went to Spain with Sir Thomas Chaloner the elder who was accredited as ambassador resident at Madrid in 1561, returning to England the same year with despatches. In 1567 he carried letters from Elizabeth I to Maximilian II, Holy Roman Emperor and the Archduke Charles at Vienna, when the queen hoped to reopen the negotiations for her marriage with the archduke, and returned with a negative answer.
In 1570 Cobham was sent to Antwerp, ostensibly on a mission of courtesy, but really to ascertain the destination of the fleet which the Duke of Alva was then equipping. He went on to Speyer, where he had audience of the Emperor (17 September), and went via Paris to Spain, accredited to Philip II as an envoy extraordinary. His instructions were to demand the release of the English ships seized by Alva in alleged retaliation for depredations committed by English privateers, and the expulsion of English Catholic refugees from Spain.
Cobham in Madrid was barely admitted to an audience of Philip, and then was immediately referred to the council. On his attempting to argue that Alva was the aggressor, De Feria suggested that he was not speaking the truth, and Cardinal Diego de Espinosa suggested that Elizabeth ought first to restore Spanish treasure taken by the privateers. Cobham then returned to England. He was knighted at Kenilworth in the summer of 1575, and in the autumn was again sent to Madrid, this time to demand religious toleration for English subjects resident and travelling in Spain, and liberty for English ambassadors resident to use the forms of the English church in their own houses; and to make an offer of mediation between Philip and the Netherlands. Alva undertook on his own responsibility to secure relaxation of the laws against heretics in favour of English residents. The proffered mediation was rejected. On his return to England, Cobham was shortly despatched to Brussels, to threaten Luis de Requesens y Zúñiga with war if he proceeded further with coercive measures; but Requesens died before Cobham could deliver the message.