Sir Christopher Guise, 1st Baronet (died 1670), of Elmore Court in Gloucestershire, England, was a Member of Parliament for Gloucestershire in 1654.
Guise was the son of William Guise of Elmore by his wife Cecilia Dennis, a daughter of John Dennis of Pucklechurch in Gloucestershire.
In 1654 Guise was elected a Member of Parliament for Gloucestershire in the First Protectorate Parliament. He was created a baronet "of Elmore" on 10 July 1661.
Guise married firstly Elizabeth Washington, daughter of Sir Lawrence Washington of Garsden, Wiltshire. He married secondly Rachel Corsellis of a noble Italian family. He was succeeded by his son Sir John Guise, 2nd Baronet.