Sidney Udenfriend (April 5, 1918 – December 29, 2001) was an American biochemist, pharmacologist, founding director of the Roche Institute of Molecular Biology, co-discoverer of a color test to detect an intestinal tumor often linked with diseased heart valves. Udenfriend was also a member of the National Academy of Sciences, a recipient of the Ames Award, Hillebrand Award, the Arthur S. Flemming award, Gairdner Award, the Van Slyke Award chief of the laboratory in the National Heart Institute, He was also a member the American Chemical Society, the American Society of Biological Chemists, American Society for Pharmacology and Experimental Therapeutics, and American Association for the Advancement of Science.