Rav Sheshet (Hebrew: רב ששת) was a Babylonian amora of the third generation and colleague of R. Naḥman bar Jacob, with whom he had frequent arguments concerning questions of religious law. His teacher's name is not definitely known, but Sheshet was an auditor at Huna's lectures (Yeb. 64b; Ket. 69a). The name is sometimes pronounced Shishat.
It is certain that he was not a pupil of Rab, since sayings of Abba Arika which did not please him were criticized by him with a disrespect which he would not have shown toward his own teacher. Concerning many of Rab's sayings, Sheshet asserted that "he must have spoken thus when he was asleep" (Yeb. 24b and parallels; comp. also Niddah 60a).
Sheshet lived first at Nehardea, where he used to study in the synagogue Shaf we-Yatib (Meg. 29a), going thence to Maḥuza (Ned. 78a, b; B. B. 121a), and later to Shilhe, where he founded an academy (Letter of Sherira Gaon, in Neubauer, M. J. C. i. 29). He was feeble in body (Pes. 108a), but had, nevertheless, an iron will and great energy (Men. 95b), and although he was blind he was compensated by a very retentive memory, for he knew by heart the entire body of tannaitic tradition, as well as its amoraic interpretations (Shebu. 41b). He hired a scholar ("tanna") acquainted with the Mishnah and the Baraita to read them to him (Sanh. 86a; Hor. 9a).