Sex-limited genes are genes that are present in both sexes of sexually reproducing species but are expressed in only one sex and remain 'turned off' in the other. In other words, sex-limited genes cause the two sexes to show different traits or phenotypes, despite having the same genotype. This term is restricted to autosomal traits, and should not be confused with sex-linked characteristics, which have to do with genetic differences on the sex chromosomes (see sex-determination system). Sex-limited genes are also distinguished from sex-influenced genes, where the same gene will show differential expression in each sex. Sex-influenced genes commonly show a dominant/recessive relationship, where the same gene will have a dominant effect in one sex and a recessive effect in the other (for example, male pattern baldness).
Sex-limited genes are responsible for sexual dimorphism, which is a phenotypic (directly observable) difference between males and females of the same species. These differences can be reflected in size, color, behavior (ex: levels of aggression), and morphology. An example of sex-limited genes are genes which instruct the male elephant seals to grow big and fight, at the same time instructing female seals to grow small and avoid fights. These genes are also responsible for some female beetles' inability to grow exaggerated mandibles, research that is discussed in detail later in this article.
The overall point of sex-limited genes is to resolve intralocus sexual conflict. In other words, these genes try to resolve the "push-pull" between males and females over trait values for optimal phenotype. Without these genes, organisms would be forced to settle on an average trait value, incurring costs on both sexes. With these genes, it is possible to 'turn off' the genes in one sex, allowing both sexes to attain (or at least, approach very closely) their optimal phenotypes.