In biology, setae /ˈsiːtiː/ (singular seta /ˈsiːtə/; from the Latin word for "bristle") are any of a number of different bristle- or hair-like structures on living organisms.
Annelid setae are stiff bristles present on the body. They help, for example, earthworms to attach to the surface and prevent backsliding during peristaltic motion. These hairs are what make it difficult to pull a worm straight from the ground. Setae in oligochaetes (a group including earthworms) are largely composed of chitin. They are classified according to the limb to which they are attached; for instance, notosetae are attached to notopodia; neurosetae to neuropodia.
Crustaceans have mechano- and chemosensory setae. Setae are especially present on the mouthparts of crustaceans and can also be found on grooming limbs. In some cases, setae are modified into scale like structures. Setae on the legs of krill and other small crustaceans help them to gather phytoplankton. It captures them and allows them to be eaten.
Insect setae are variously called hairs, macrotrichia, or chaetae. They are unicellular and formed by the outgrowth of a single epidermal cell (trichogen). They are generally hollow and project through a secondary or accessory (tormogen) cell as it develops. The setal membrane is not cuticularized and movement is possible. This serves to protect the body.