Seroconversion

In immunology, seroconversion is the time period during which a specific antibody develops and becomes detectable in the blood. After seroconversion has occurred, the disease can be detected in blood tests for the antibody. During an infection or immunization, antigens enter the blood, and the immune system begins to produce antibodies in response. Before seroconversion, the antigen itself may or may not be detectable, but the antibody is, by definition, absent. During seroconversion, the antibody is present but not yet detectable. Any time after seroconversion, the antibodies can be detected in the blood, indicating a prior or current infection.

The physical structure of an antibody allows it to bind to a specific antigen to form a complex. Because of this binding, if the amounts of antigen and antibody in the blood are equal, each molecule will be in a complex and be undetectable. The antibody or antigen is only detectable in the blood when there is more of one than the other.

Early in an infection, the antigen molecules outnumber the antibody molecules, and there will be unbound antigen that may be detectable, while all the antibody molecules are bound. After seroconversion, there is more antibody than antigen, so there is a detectable amount of free antibody, while all the antigen is bound and undetectable.

During seroconversion, when the amounts of antibody and antigen are very similar, it may not be possible to detect free antigen or free antibody. This may give a false negative result when testing for the infection. This time is referred to as the window period.

Serology (testing for antibodies) is used to determine if specific antibodies are in an organism's blood. Serostatus is a term denoting the presence or absence of particular antibodies in an individual's blood. Before seroconversion, the blood test is seronegative for the antibody; after seroconversion, the blood test is seropositive for the antibody.

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