Seneca Creek is a 5.8-mile-long (9.3 km) stream in Montgomery County, Maryland, USA, roughly 16 miles (26 km) northwest of Washington, D.C. It drains into the Potomac River.
The creek begins with two main tributaries:
These tributaries converge near Darnestown. Another major tributary, Dry Seneca Creek, empties into Seneca Creek west of Darnestown. The creek continues south and passes under Seneca Aqueduct/Riley's Lock (Lock 24) of the Chesapeake and Ohio (C&O) Canal before it flows into the Potomac River. There is about a 600 feet (180 m) change in elevation from the stream's upper sources to its mouth at the Potomac. Seneca Creek has a watershed area of 121 square miles (310 km2).
Depending on conditions, parts of the creek are navigable by light watercraft, such as kayaks or canoes. Near Riley’s Lock there is a boat ramp into the creek which provides access to the Potomac River.
An area of about 6,300 acres (25 km2) along 14.75 miles (23.74 km) of the creek has been set aside as Seneca Creek State Park. It has trails including the 16.5 miles (26.6 km) Seneca Creek Greenway Trail, the 10 miles (16 km) Schaeffer Farm Trail, and many shorter and easier trails. Parking and picnic areas are provided at various locations in the park. Long Draught Creek, a small tributary north of Gaithersburg has been dammed to form the 90 acres (0.36 km2) Clopper Lake which is the centerpiece of the park's day use area. This area includes multiple picnic areas, a disc golf course, boat rentals for the lake, and restroom facilities. Just west of the creek's mouth is the Seneca Quarry, the quarry that provided the red sandstone for the Smithsonian Castle and locks 8 - 27 of the C&O Canal. The remains of the 1837 stone cutting mill are still intact, though unmarked; above the quarry is the restored quarry masters house. Both are within state park lands.