"Seek & Destroy" is a song by American heavy metal band Metallica and ninth track from their debut studio album, Kill 'Em All. It was also featured on the demo No Life 'til Leather. It was the first song the band recorded in a studio. "Seek & Destroy" has been frequently performed at the group's concerts since its live debut in 1982 and had been Metallica's closing song from the Madly in Anger with the World Tour to the Metallica By Request Tour. It is the third most performed song in the band's history, having been played 1,359 times as of August 2016, behind only Creeping Death (1,446) and Master of Puppets (1,503).

During the 2004 documentary film about Metallica, Some Kind of Monster, the song is used when footage of the band down the years is shown highlighting the progression in the group's appearance and sound over time. In AOL Radio's list of the 10 Best Metallica Songs, "Seek & Destroy" was ranked at number 4, and Allmusic's Steve Huey chose the song as an AMG Track Pick from Kill 'Em All.

Following the terrorist attacks on September 11, 2001, the song was placed on the list of post-9/11 inappropriate titles distributed by Clear Channel.

The song is about feeling the urge to kill, but not literally doing it. During the Kill 'Em All for One Tour, Hetfield would jokingly say that it was about hunting. It is said to be heavily influenced by the Diamond Head song "Dead Reckoning". The first three mini solos are derived from the song "Princess of the Night" by Saxon. Metallica added the final solo. Since the song's debut on Kill 'Em All, Hammett has apologized for the unusual pitch of the string bend which occurs at 3:47 to 3:48, during the solo, is in fact a mistake or "bum note".

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