The Secotans were one of several groups of American Indians dominant in the Carolina sound region, between 1584 and 1590, with which English colonizers had varying degrees of contact. Secotan villages included the Secotan, Aquascogoc, Dasamongueponke, Pomeiock (Pamlico) and Roanoac. Other local groups included the Chowanoke (including village Moratuc), Weapemeoc, Chesapeake, Ponouike, Neusiok, and Mangoak (Tuscarora), and all resided along the banks of the Albemarle and Pamlico sounds. They spoke Carolina Algonquian language an Eastern Algonquian language.
In the Carolinas, Colonization did not exist as a straight-line transition, from Native American to European rule. A rivalry marked the relationship between the two European powers, the English and the Spanish. Rivalries also existed between the Native American groups. Additionally, the Europeans often found themselves caught in the middle of conflicts, which existed between Native American groups. Each group, European or Native American placed the interest of their group over the interest of all others. The English, the Spanish, and the Native American groups they had contact with each acted against the others, as counter-colonizers of the Carolinas as exhibited through the study of Roanoke Island.
In 1490, prior to England's entry into North American colonialism, the Treaty of Medina del Campo lowered tariffs between England and Spain, and ushered in an era of increased trading between the two countries. The marriage of Henry VIII of England and Catherine of Aragon (Spain) sealed the treaty. During this time, many English traders moved to southern Spain, in the area of Andalusia, and trade flourished. In 1533, Spanish officials began to harass the English in Spain, who were required as Englishmen to "swear under oath" that Henry VIII was the head of the church. The requirement of the oath made the Englishmen in Spain subject to persecution, under charges of heresy, by the Spanish Inquisition.