Sebastian Weigle (born 1961 in Berlin) is a German horn player and conductor. He is known for conducting the works of Richard Wagner in Bayreuth and the Frankfurt Opera.
Weigle studied at the Hochschule für Musik "Hanns Eisler" in horn, piano and conducting. In 1987 he founded the Berlin Chamber Choir, and later he led the New Berlin Chamber Orchestra. He was principal horn player in the orchestra of the Berlin State Opera for 15 years. He also was a member of the jazz orchestra "Vielharmonie" in East Berlin.
In 1993 he became chief conductor of the National Youth Symphony Orchestra in Brandenburg and in 1997, principal conductor of the Staatsoper Unter den Linden. He has performed at many opera houses, including the Semperoper, the Frankfurt Opera, the Vienna Volksoper, the Cincinnati Opera, the Vienna State Opera and the Metropolitan Opera in New York.
In 2003, he performed Die Frau ohne Schatten by Richard Strauss at the Frankfurt Opera with director Christof Nel and was named "Conductor of the Year" by the German magazine Opernwelt. He received the title again in 2005 and 2006. From 2004 to 2008 he was music director of the Gran Teatre del Liceu in Barcelona.
Weigle conducted a new production of Wagner's Die Meistersinger von Nürnberg at the Bayreuth Festival in 2007, staged by Katharina Wagner, as well as repeated performances in the following years.