Science and technology in the United Kingdom has a long history, producing many important figures and developments in the field. Major theorists from the UK include Isaac Newton whose laws of motion and illumination of gravity have been seen as a keystone of modern science and Charles Darwin whose theory of evolution by natural selection was fundamental to the development of modern biology. Major scientific discoveries include hydrogen by Henry Cavendish, penicillin by Alexander Fleming, and the structure of DNA, by Francis Crick and others. Major engineering projects and applications pursued by people from the UK include the steam locomotive developed by Richard Trevithick and Andrew Vivian, the jet engine by Frank Whittle and the World Wide Web by Tim Berners-Lee. The UK continues to play a major role in the development of science and technology and major technological sectors include the aerospace, motor and pharmaceutical industries.
England and Scotland were leading centres of the Scientific Revolution from the 17th century and the United Kingdom led the Industrial Revolution from the 18th century, and has continued to produce scientists and engineers credited with important advances. Some of the major theories, discoveries and applications advanced by people from the UK are given below.
The UK plays a leading part in the aerospace industry, with companies including Rolls-Royce playing a leading role in the aero-engine market; BAE Systems acting as Britain's largest and the Pentagon's sixth largest defence supplier, and large companies including GKN acting as major suppliers to the Airbus project. Two British-based companies, GlaxoSmithKline and AstraZeneca, ranked in the top five pharmaceutical companies in the world by sales in 2009 and UK companies have discovered and developed more leading medicines than any other country apart from the US. The UK remains a leading centre of automotive design and production, particularly of engines, and has around 2,600 component manufacturers. Investment by venture capital firms in UK technology companies was $9.7 billion from 2010–2015.