Sanuki Domain (佐貫藩 Sanuki-han?) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Kazusa Province (central modern-day Chiba Prefecture). It was centered on Sanuki Castle in what is now the city of Futtsu, Chiba.
The original Sanuki Castle was built by the Satomi clan, rulers of most of the Bōsō Peninsula during the Sengoku period. Following the Battle of Odawara in 1590, the Kantō region by was assigned to Tokugawa Ieyasu by the warlord Toyotomi Hideyoshi, who also restricted the Satomi to Awa Province for their lukewarm support of his campaigns against the Late Hōjō clan. Tokugawa Ieyasu appointed Naito Ienaga, one of his hereditary retainers, to be daimyō of the newly formed 20,000 koku Sanuki Domain.
During the Siege of Fushimi in 1600 prior to the Battle of Sekigahara, Naito Ienaga was one of the last defenders of Fushimi Castle to fall to the forces of Ishida Mitsunari. He was succeeded by his son, Naito Masanaga, who was awarded an additional 10,000 koku for his efforts at the Siege of Osaka. He gained another 10,000 koku for his participation in the suppression of the Satomi clan at Tateyama Domain in Awa Province, and yet another 5,000 koku when Shogun Tokugawa Hidetada visited on an extended falconry expedition, thus bringing his total revenues to 45,000 koku. He was subsequently transferred to Iwakidaira Domain in Mutsu Province.