Santa Francesca Romana (Italian: Basilica di Santa Francesca Romana), previously known as Santa Maria Nova, is a church in Rome, Italy, situated next to the Roman Forum in the rione Campitelli.
The church was built in the second half of the tenth century, incorporating an eighth-century oratory that Pope Paul I excavated in the wing of the portico of the Temple of Venus and Roma; it was named Santa Maria Nova (or "Nuova", "new St. Mary"), to distinguish it from the other Roman Forum church devoted to St. Mary, Santa Maria Antiqua ("ancient St. Mary"), which had become dilapidated in the tenth century; it was rebuilt by Pope Honorius III in the thirteenth century, when the campanile was built and the apse was decorated with mosaics of a Maestà, the Madonna enthroned accompanied by saints. The interior has been altered since. Since 1352 the church has been in the care of the Olivetans. In the 16th century, the church was rededicated to Frances of Rome (Francesca Buzzi), who was canonized in 1608 and whose relics are in the crypt. Its travertine porch and façade is by Carlo Lambardi, and was completed in 1615.
The inscriptions found in Santa Francesca Romana (S. Maria Nuova), a valuable source illustrating the history of the church, have been collected and published by Vincenzo Forcella.
The interior, a single nave with side chapels, was rebuilt by Lombardi in the years preceding Francesca Buzzi's canonization, beginning in 1595. In the middle of the nave is the rectangular schola cantorum of the old church, covered in Cosmatesque mosaics. Another prominent feature is the confessional designed by Gian Lorenzo Bernini (1638–49), in polychrome marbles with four columns veneered in jasper.