Santa María la Antigua del Darién, formerly also known as Dariena, was a Spanish colonial town founded in 1510 by Vasco Núñez de Balboa, located in present-day Colombia approximately 40 miles south of Acandí, within the municipality of Unguía in the Chocó Department. It was the first city founded by conquistadors in mainland America. After Pascual de Andagoya, a Spanish-Basque conquistador under the direction of Panama governor Pedrarias Dávila, founded Panama City in 1519, Santa María la Antigua del Darién was abandoned and in 1524 was attacked and burned by the indigenous people.
Coordinates: 8°12′53″N 77°01′17″W / 8.214861°N 77.021361°W