Santa Isabel (Spanish pronunciation: [ˈsanta isaˈβel], Saint Elizabeth) is a municipality of Puerto Rico located in the southern coast, south of Coamo; east of Juana Díaz; and west of Salinas. Santa Isabel is spread over 7 wards and Santa Isabel Pueblo (the downtown area and the administrative center of the city). It is the principal city of the Santa Isabel Micropolitan Statistical Area and is part of the Ponce-Yauco-Coamo Combined Statistical Area.

Santa Isabel is known as "La Ciudad de los Potros" ("The City of the Colts").

Santa Isabel was founded on October 5, 1842 by Antonio Vélez.

The surrounding areas produces fruits and vegetables.

Aerospace electrical and electronic, metal products and nutritional products.

Santa Isabel is known as "Tierra de Campeones" (Land of Champions) because of its rich sports tradition (especially in Baseball). The city is home to the Santa Isabel Potros baseball team. The Potros won the 1992 National Championship of the Federación de Béisbol Aficionado de Puerto Rico. The team plays its home games at Estadio Municipal Luis Guillermo Moreno.

All municipalities in Puerto Rico are administered by a mayor, elected every four years. Enrique "Quique" Questell (of the New Progressive Party) was elected at the 2004 general election.

The city belongs to the Puerto Rico Senatorial district VI, which is represented by two Senators. In 2012, Miguel Pereira Castillo and Angel M. Rodríguez were elected as District Senators.

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