Sir Samuel St. Swithin Burden Whalley (1800 – 3 February 1883) was a British Radical politician.
A member of a Lancashire family "of great antiquity", he was the son of Samuel Whalley of Weddington Hall, Warwickshire, and was educated at Clare Hall, Cambridge, gaining his bachelor's degree in 1822 and master's in 1825. In 1827 he was knighted, at which date he was living in Devon.
By the 1830s Whalley was living in the St John's Wood area of the parish of St Marylebone, a rapidly developing suburb of London. In 1832 Whalley sought to be nominated as a candidate for the newly enfranchised constituency of Marylebone, London. There was opposition to his candidacy as he was virtually unknown in the area. Questions were also raised about the manner in which he had obtained his knighthood, which was felt to have been in exchange for supporting the election of the Tory, Sir Nicholas Tindal as MP for Cambridge University.
Although he failed to be selected on this occasion, a by-election occurred in the following year when one of the sitting members of parliament resigned. He was successfully nominated, and he described himself as "not backed by either church or aristocracy but... the representative of industry". He promised to be a "pure and independent" member, and set out his political views: he was in favour of "a rigid system of economy in all branches of the state" and "a revision of the system of tithes, and the appropriation of the surplus revenues of the church to the education of the people". He also advocated the abolition of slavery, reduction of taxation, destruction of monopolies, a secret ballot, and a three-year parliamentary term.