Samuel B. Romaine was an American lawyer and politician.
He was the son of Colonel Benjamin Romaine (1764–1844, several times Grand Sachem of the Tammany Society).
Samuel Romaine was a member of the New York State Assembly in 1816–17 and from 1819 to 1822, and was Speaker in 1822.
His son Benjamin Romaine, Jr. was a well-known Whig politician in the 1850s in New York's 15th Ward.