Saitō Toshimitsu (斎藤 利三?, 1534 – July 6, 1582) was a Japanese samurai of the Sengoku period. Once a retainer of Inaba Ittetsu, he later joined Akechi Mitsuhide. Oda Nobunaga became extremely angry when hearing of this event, and would have killed him if not for Mitsuhide's intervention. Toshimitsu was also vital for the Akechi action at Honnō-ji and the Battle of Yamazaki.
Lady Kasuga was the daughter of Toshimitsu.