SB-258585

SB-258585
Identifiers

IUPAC name 4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide
CAS Number	209480-63-7^Y
PubChem CID	3248571
IUPHAR/BPS	3232
ChemSpider	2498938^N
ChEMBL	CHEMBL60264^N
Chemical and physical data
Formula	C₁₈H₂₂IN₃O₃S
Molar mass	487.354 g/mol
3D model (Jmol)	Interactive image
SMILES C3CN(C)CCN3c1cc(ccc1OC)NS(=O)(=O)c2ccc(I)cc2
InChI InChI=1S/C18H22IN3O3S/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16/h3-8,13,20H,9-12H2,1-2H3^N Key:BDHMSYNBSBZCAF-UHFFFAOYSA-N^N
^NY (what is this?)

SB-258585 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist, with a Ki of 8.9nM. It is used in its ¹²⁵I radiolabelled form to map the distribution of 5-HT₆ receptors in the brain.

SB-258585 and other 5-HT₆ antagonists show nootropic effects in animal studies, as well as antidepressant and anxiolytic effects, and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.

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Wikipedia