"Run Up" is a song by American electronic band Major Lazer from their upcoming fourth studio album, Music Is the Weapon (2017). The song features Canadian musician PartyNextDoor, and Trinidadian-born American rapper Nicki Minaj. The song was released on YouTube in January 26, 2017, by Mad Decent and Because Music. The song was written by primary Major Lazer member Diplo, Stargate, Jr. Blender, PartyNextDoor, Minaj, and Philip Meckseper, while the song's production was handled by Major Lazer, Stargate, and Jr. Blender.

"Run Up" has a length of three minutes and twenty-three seconds. According to the sheet music published by Kobalt Music Publishing America, Inc on Musicnotes.com, it's written in the key of E Major set in a 4
4 time signature at a moderate tempo of 108 beats per minute. The vocal range spans from the low note C♯₃ to the high note C♯₅, while the music follows the chord progression of A–C♯_m–E–B. Musically, "Run Up" is a dancehall song. PartyNextDoor and Minaj sing using the Jamaican Patois accent.

"Run Up" received generally positive reviews from music critics. Reviewing the song, Ryan Reed from Rolling Stone described it as "a suave blend of high-pitched vocal samples, warped guitar chords and a signature Caribbean music groove." Him praised the presence of Minaj and PartyNextDoor on the song, "PartyNextDoor croons smooth come-ons throughout the track, but Minaj amps up the intensity with a reliably boastful verse." Kat Being of Billboard call it as "a great follow-up to "Cold Water" (2016). Bianca Gracie from Fuse gave a positive review to the song, writing, "Minaj and Party bring their Trinidadian and Jamaican roots to the track, as the rapstress drops boastful verses laced with swagger, sex appeal and patois." The written also praised the vocal of the singer PartyNextDoor on the song, she wrote: "PartyNextDoor adds his crooning vocals to the opening and hook, which is backed by Major Lazer's island-tinged production."

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