Romantic medicine is part of the broader movement known as Romanticism, most predominant in the period 1800–1840, and involved both the cultural (humanities) and natural sciences, not to mention efforts to better understand man within a spiritual context ('spiritual science'). Romanticism in medicine was an integral part of Romanticism in science.
The impetus for Romantic ideas in medicine came from the Great Britain, and more specifically Scotland - John Hunter (1728–93) - and the idea of life as a principle not reducible to material constructs, and John Brown (1735–88), founder of the Brunonian system of medicine (see also, Romanticism in Scotland#Science). The nexus for Romantic Medicine was Germany, largely nurtured and guided by German natural scientific inquiries regarding the vital aspects of nature, such as that of Johann Friedrich Blumenbach (1752–1840) and his influential ideas regarding a life principle (Bildungstrieb), a formative drive (nisus formatives) as well as a philosophical tradition that emphasized the dynamic aspects of man and nature, and their essential relationship as part of a unity - German idealism and Naturphilosophie - all guided by Immanuel Kant's (1724–1804) challenge calling for critical inquiry as the basis for science.
The essence of romantic medicine was to overcome the deep crisis that Western medicine found itself in during the latter half of the 1700s by means of a science of life (pathology and physiology grounded in history) that went beyond the simple application of the method of the inertial sciences (physics and chemistry, grounded in mathematics) that had worked so well for inert nature, but was found wanting when applied to vital nature, but also a science of life that went beyond the idea of medicine as a subjective art largely to be left to individual practice. The Zeitgeist of Romantic medicine sought to unite the uneasy partnership of material natural science and subjective clinical practice to create a true scientific foundation for Western medicine (see also Romanticism and epistemology)