Rodrigo Ponce de Leon, Marquis de Cadiz (1443-1492) was one of the Castilian military leaders in the conquest of Granada. In 1482 he led the Castilian forces that captured Boabdil. He had earlier been one of the military leaders in the Castilian War of Succession. Juan Pacheco was his father-in-law. He was made 1st Duke of Cádiz in 1484 and succeeded briefly by his heir Francisca Ponce de León y de la Fuente.
Ponce de León is also related to: