Richard Ambler
| Richard Penry Ambler | |
|---|---|
| Born |
26 May 1933 Bexleyheath, London, England |
| Died | 27 December 2013 (aged 80) Edinburgh, Scotland |
| Alma mater | Pembroke College, Cambridge |
| Occupation | Molecular biologist |
| Known for | Research into antibiotic resistance |
Richard Penry Ambler (26 May 1933 – 27 December 2013) was an English molecular biologist who conducted groundbreaking research into the evolution of antibiotic-resistant bacteria. Ambler was the first scientist to publish an amino acid sequence of a bacterial protein, and had a lengthy academic career at Edinburgh University.
Ambler was born in 1933 to Henry Ambler, a state-employed chemist, and Anne Evans, a civil servant, in Bexleyheath, London. In 1940, the family moved to Pune, India, where Ambler's father conducted wartime explosives research. Ambler later returned to England to attend boarding school at Haileybury , before heading to Pembroke College, Cambridge in 1954 to study natural sciences. He remained at Cambridge to complete his PhD on bacterial proteins, under the tutelage of the Nobel Prize-winning scientist Fred Sanger. In 1963, Ambler published the first amino acid sequence of a bacterial protein, developing new methods of protein sequencing to determine the structure of the protein. Cytochrome c remains an important object of study for modern biologists.
In 1965, Ambler joined the newly created Department of Molecular Biology at Edinburgh University. He began a longstanding research project on the increasing resistance of certain bacteria to penicillin and other antibiotics, making important discoveries related to bacterial gene transfer and enzyme development. In particular, Ambler found that horizontal gene transfer played a key role in the development of antibiotic resistance. He headed the Department of Molecular Biology between 1984 and 1990, helping to reorganize it into more specialized sub-departments, and became a member of the European Molecular Biology Organisation in 1985. He retired from Edinburgh University in the mid-1990s, and died in Edinburgh in December 2013.
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