Rhoesaces (Greek: Ῥοισάκης) was the brother of Spithridates, a satrap of Ionia and Lydia, with whom he might have held the possession of satrap. Rhoesaces served in the earlier campaigns of Artaxerxes III in Phoenicia and in Egypt were he was singled out for his 'valour and loyalty' to serve alongside allied Theban troops. He took part in the battle of the Granicus in 334 BC where he was killed. According to Diodorus of Sicily, after his brother Spithridates was killed by Alexander the Great the fight between him and Rhoesaces happened like this:
However, Arrian records Spithridates as the one who lost his arm to Cleitus and thus Diodorus seems to confound Rhoesaces with his brother Spithridates. According to Arrian, Rhoesaces hit hard Alexander on his helmet before Alexander managed to kill him.