Rhenish Hesse or Rhine-Hesse (German: Rheinhessen) is a region and a former government district (Regierungsbezirk) in the German state of Rhineland-Palatinate, made up of those territories west of the Upper Rhine river that from 1816 were part of the Grand Duchy of Hesse and of the People's State of Hesse until 1945. The hilly countryside is largely devoted to vineyards, comprising the Rheinhessen wine region.
Rhenish Hesse, stretches from the Upper Rhine Plain on the west bank of the Rhine up to the Nahe and Alsenz rivers in the west and down to the mouth of the Isenach in the south. The region borders on the Rhineland in the northwest, on the Palatinate in the southwest, and on South Hesse beyond the Rhine. The Rhenish-Hessian Hills along the Selz river, also called the "land of the thousand hills", reach up to 358 m (1,175 ft) at the summit of the Kappelberg and about 330 m (1,080 ft) in Rhenish-Hessian Switzerland.
The Mainz Basin, a Cenozoic marine basin, covered the area about 38 to 12 million years ago. The landscape is characterised by large Loess and Marl deposits. Due to the favourable climatic conditions of Rhenish Hesse, agriculture covers most of the region. As the Hunsrück and Taunus ranges protect it from cold winds, wine and fruit production is practised on a large scale.