"Rescue Me" is a rhythm and blues song first recorded and released as a single by Fontella Bass in 1965. The original versions of the record, and BMI, give the songwriting credit to Raynard Miner and Carl William Smith, although many other sources also credit Bass herself as a co-writer. It would prove the biggest hit of Bass's career, reaching #1 on the R&B charts for four weeks and placing at #4 on the Billboard Hot 100. "Rescue Me" also peaked at number eleven on the UK Singles Chart.

According to writer Robert Pruter in his book Chicago Soul, the song emerged from a songwriting and rehearsal, or "woodshedding", session at Chess Records: " 'Rescue Me' was a terrific example of the Chess studio system at its finest... One Saturday in August 1965, Bass was sitting in a rehearsal studio with producers-writers Carl Smith and Raynard Miner. They were fooling around with the song when arranger Phil Wright walked in, and the ensuing four-way jam session brought forth 'Rescue Me'. [Billy] Davis produced the side..." Bass claimed that, although Smith, Miner and Davis had assured her that her contribution to authorship of the song's lyrics would be acknowledged, this was never done.

Bass recorded the song in three takes at Chess Studios in Chicago. Minnie Riperton provided background vocals, and Maurice White and Louis Satterfield, later of Earth, Wind & Fire, were on drums and bass respectively. Other musicians on the record included Pete Cosey and Gerald Sims on guitar, Leonard Caston on piano, Sonny Thompson on organ, and Charles Stepney on vibes. According to Bass, the call-and-response moans heard in the song were unintentional. In an interview with The New York Times in 1989, she said, “When we were recording that, I forgot some of the words... Back then, you didn’t stop while the tape was running, and I remembered from the church what to do if you forget the words. I sang, ‘Ummm, ummm, ummm,’ and it worked out just fine.”

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