The Regius Professorship of Physic is a Regius Professorship in Medicine at the University of Dublin, Trinity College. The seat dates from at least 1637, placing it amongst the oldest academic posts at the university. Mention is made in the college's Register for 1598 of an annual grant of £40 from the government for a "Physitian's pay"; this is sometimes held to be the provision made for the Chair of Physic, but it is possible that it may have been in granted for medical services required by the troops stationed in Dublin.
By 1700, the chair was considered part of the senior academic staff, alongside the Provost and Fellows (the professorships in other subjects being confined to Fellows at that time).