The estrous cycle or oestrus cycle (derived from Latin oestrus 'frenzy', originally from Greek οἶστρος oîstros 'gadfly') comprises the recurring physiological changes that are induced by reproductive hormones in most mammalian therian females. Estrous cycles start after sexual maturity in females and are interrupted by anestrous phases or by pregnancies. Typically, estrous cycles continue until death. Some animals may display bloody vaginal discharge, often mistaken for menstruation.
Mammals share the same reproductive system, including the regulatory hypothalamic system that produces gonadotropin-releasing hormone in pulses, the pituitary gland that secretes follicle-stimulating hormone and luteinizing hormone, and the ovary itself that releases sex hormones including estrogens and progesterone.
However, species vary significantly in the detailed functioning. One difference is that animals that have estrous cycles resorb the endometrium if conception does not occur during that cycle. Animals that have menstrual cycles shed the endometrium through menstruation instead. Another difference is sexual activity. In species with estrous cycles, females are generally only sexually active during the estrus (oestrus) phase of their cycle . This is also referred to as being "in heat". In contrast, females of species with menstrual cycles can be sexually active at any time in their cycle, even when they are not about to ovulate.