Rancho Los Guilicos was a 18,834-acre (76.22 km2) Mexican land grant in present day Sonoma County, California given in 1837 by Governor Juan B. Alvarado to John (Juan) Wilson. The grant extended along Sonoma Creek, south of Santa Rosa from Santa Rosa Creek south to almost Glen Ellen, and encompassed present day Oakmont, Kenwood and Annadel State Park.
The four square league grant was made to Captain John Wilson (1797 – 1861), a Scottish-born sea captain and trader, who came to California in 1830. In 1837 Wilson married María Ramona Carrillo de Pacheco (1812–1888), widow of José Antonio Romualdo Pacheco, who was killed at the Battle of Cahuenga Pass in 1831. Carrillo, was a daughter of Maria Ygnacia Lopez de Carrillo, the grantee of Rancho Cabeza de Santa Rosa. María's sister married General Mariano Guadalupe Vallejo. María Ramona Carrillo de Pacheco was also the grantee of Rancho Suey. Wilson and his business partner, James Scott (-1851), also owned Rancho El Chorro and Rancho Cañada de los Osos y Pecho y Islay in San Luis Obispo County. In 1845, Wilson moved his family from San Luis Obispo to Rancho Cañada de los Osos & Pacheco y Islay, built an adobe home and lived there until his death in 1860.
With the cession of California to the United States following the Mexican-American War, the 1848 Treaty of Guadalupe Hidalgo provided that the land grants would be honored. As required by the Land Act of 1851, a claim for Rancho Los Guilicos was filed with the Public Land Commission in 1852, and the grant was patented to John Wilson in 1886.